E-news: Aldosterone directly affects apelin expression and secretion in adipocytes

The objective of this study was to investigate the effects of high aldosterone levels on apelin expression and secretion and the underlying mechanisms involved in adipocytes.

In vivo, a single-dose Ald injection acutely decreased apelin serum levels and adipose tissue apelin production, which demonstrates a clear inverse relationship between the levels of plasma Ald and plasma apelin.

Experiments using 3T3-L1 adipocytes showed that Ald decreased apelin expression and secretion in a time- and dose-dependent manner. This effect was reversed by glucocorticoid receptor (GR) antagonists or GR (NR3C1) knockdown; furthermore, putative HREs were identified in the apelin promoter.

Subsequently, it was verified that both glucocorticoids and mineralocorticoids regulated apelin expression through GR activation, although no synergistic effect was observed.

There is a direct interaction between Ald and apelin in adipocytes, which has important implications for hyperaldosteronism or primary aldosteronism-associated cardiometabolic syndrome and hoists apelin on the list of potent therapeutic targets for PA.

Read more in the Journal of Molecular Endocrinology.