E-news: Perinatal BPA exposure disrupts stress responses

Endocrine disrupting chemicals such as bisphenol A are found in many household and industrial products. These chemicals interfere with hormone synthesis, secretion, action or elimination, resulting in various health problems.

Panagiotidou et al have studied the effect of a low chronic exposure of BPA during the perinatal period on the stress induced hypothalamic-pituitary-adrenal (HPA) axis response of rats at puberty.

The dose used in the study was below the equivalent lowest observed adverse effect level for humans.

They found that the HPA axis was altered following BPA exposure in both basal conditions and following stress, and was sexually dimorphic. These results provide further evidence that regulation of EDCs should take into account the low dose effects f these chemicals.

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