E-news: AGEs contribute to osteopenia in diabetes

Osteoporosis is a common complication of diabetes and is associated with a reduction in bone formation.

Weinberg et al investigated the mechanisms by which advanced glycation end products (AGEs) and oxidative stress (OxS) cause osteopenia.

They found that AGEs induce the apoptosis of bone marrow stromal cells through a pathway involving the production of TNFa, p38 MAPK signalling and OxS.

The effects seen in BMSCs probably also extend to the osteoprogenitor cell population, suggesting a reduction in the number of cells available for bone remodelling and regeneration.

AGEs have also been reported to suppress the osteoblastic differentiation of bone marrow stromal stem cells. Thus, hyperglycaemia and the production of AGEs provide a multifaceted mechanism for the development of osteopenia through the loss of osteoprogenitor cells.

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